Asthma, pathophysiology, risk factors, Chronic Pathophysiologic Changes, mortality, cellular processes, overreaction, airway obstruction, symptoms, asthma control, strategy management
The pathophysiology of asthma can be seen as one of the critical points in the comprehensive investigation of a chronic airway condition involving anatomy and clinical symptoms. In the context of practice as an advanced practice nurse, linking pathophysiology to the analysis of disease has become essential, as the underlying pathophysiology directly correlates to the presenting symptoms, signs, and severity of the disease. Symptoms of asthma are mainly ascribed to one organ system. The underlying cellular processes often affect multiple related systems, emphasizing the need for a holistic appreciation of disease pathogenesis. The paper deals with asthma pathophysiology, which includes the bronchial mucosa's three main components and how they relate to the presented symptoms and Nancy Smith's disease course.
[...] (2023, June 24). Pathophysiology Of Asthma. Nih.gov; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK551579/ ?Yaneva, M., & Razvigor Darlenski. (2021). The link between atopic dermatitis and asthma- immunological imbalance and beyond. Asthma Research and Practice, 7(1). [...]
[...] The recurrent nature of the inflammation will also trigger structural alterations within the airways, known as airway remodeling. The thickening of the basement membrane, the hypertrophy, the hyperplasia of smooth muscle in the airways, and the increased numbers of glands that secrete mucus are among the changes. Such structural alteration may lead to permanent airway obstruction, advancing the ailment's severity. Symptoms and Pathophysiology The patient's symptoms can be directly attributed to the specific pathophysiological mechanisms that characterize asthma. The breathing difficulty characterized by shortness of breath while climbing stairs or walking to the mailbox is caused by airway hyperresponsiveness and inflammation, leading to bronchoconstriction and the narrowing of the airways, blocking airflow. [...]
[...] Conclusion The pathophysiology of asthma is determined by the interplay between airway hyperresponsiveness, airway inflammation, and airway remodeling, which are the main factors responsible for the appearance and worsening of the disease. The reasons for Nancy's aggravation of asthma during the presentation are associated with these exact underlying pathophysiological aspects. Recognition of the genetic, pharmacogenetic, and environmental exposure risk factors, as well as the relationship between atopy and asthma, is pivotal to designing management strategies and preventive measures for those afflicted by the chronic asthma condition in the long term. References Barnes, P. [...]
[...] J., & Drazen, J. M. (2002). Pathophysiology of Asthma. Elsevier EBooks, 343-359. https://doi.org/10.1016/b978-012079028-9/50110-1 ?Sanna Toppila-Salmi, Riikka Lemmetyinen, Sebastien Chanoine, Jussi Karjalainen, Juha Pekkanen, Bousquet, J., & Valérie Siroux. (2021). Risk factors for severe adult-onset asthma: a multi-factor approach. BMC Pulmonary Medicine, 21(1). https://doi.org/10.1186/s12890-021-01578-4 ? Sinyor, B., & Livasky Concepcion Perez. [...]
[...] Those with atopy are more vulnerable to developing these conditions, as the inflammation pathways involved in the progression of both conditions are essentially the same. The relationship between atopy and asthma is well-known, and studying this connection is crucial in the complete care of the patient with this disease. Chronic Pathophysiologic Changes and Asthma Morbidity and Mortality The instability of asthma control may cause long-term functional changes in the respiratory system that will have a direct relationship with the morbidity and mortality of asthma. [...]
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